AalphaC-15N3-2-Amino-α-carboline-sup-15-sup-N-sub-3-sub-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

AalphaC-15N3

Cat.No.:HY-W700491

CASNo.:1189920-50-0

Synonyms:2-Amino-α-carboline-15N;AαC-15N

33

分⼦式:C₁₁H₉₁₅N₃

分⼦量:186.19

作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite

作⽤通路:Others;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AalphaC-15N3(2-Amino-α-carboline-15N3)是15N标记的AalphaC。AalphaC(AαC)是⼀种潜在的致癌物

，具有致癌活性。AalphaC在烟草烟雾中作为⼀种重要的⽣物标志物，与烟草烟雾暴露相关。AalphaC的尿液

浓度在专门吸烟者中显著⾼于⾮吸烟者，显⽰出其在监测烟草暴露中的重要性。AalphaC的⽔平会随着⾎清尼

古丁⽔平的增加⽽显著上升，这表明其与烟草使⽤的密切关系。此外，⾷⽤⾼温烹饪的⽜⾁会显著增加尿液中

AalphaC的含量，⽽⾷⽤蔬菜则与AalphaC浓度下降相关。吸烟半包⾹烟与AalphaC量的显著增加相关，这进

⼀步确认了AalphaC的⽣物学活性及其与饮⾷习惯的关联。

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019

Feb;53(2):211-216.

[2].EvaluationofTobaccoSmokeandDietasSourcesofExposuretoTwoHeterocyclicAromaticAminesfortheU.S.Population:NHANES