细胞凋亡华子春.ppt

下载文档

0
0
约6.28千字
约 10页
2025-02-08 发布于上海
举报
版权申诉
保障服务

细胞凋亡华子春.ppt

1、本文档共10页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

体内细胞凋亡检测紫杉醇治疗小鼠肺癌肿瘤肺癌肿瘤组织的免疫组织化学分析ApoptosisDoesNotDamageNeighboringCellsMorphologicalfeaturesofapoptosis:CytoskeletoncollapsesNuclearenvelopedisassemblesNuclearDNAbreaksupintofragmentsCellsurfacechangessothatthecellcanberapidlyphagocytosedTheconsequenceisneatdeath---nodamagetotheneighboringcellsDeathbycellnecrosis;cellcontentsspilledallovertheneighborsCellapoptosis,inculturedishCellapoptosis,intissue.ShowingphagocytosisFormsofcelldeathNecrosisApoptosisPassiveActivePathologicalPhysiologicalor pathologicalSwelling,lysis Condensation,cross-linkingDissipatesPhagocytosedInflammation NoinflammationExternallyinduced Internallyor externallyinducedAPOPTOSISProgrammedcelldeathOrderlycellularselfdestructionProcess:ascrucialforsurvivalofmulti-cellularorganismsascelldivisionMULTIPLEFORMS???ApoptosisIsImportanttotheDevelopmentandSurvivaloftheOrganismInhuman,billionsofcellsdieinbonemarrowandintestineeverydayWhysucha“waste”?NormaldevelopmentBalancingcelldivisionRemovingabnormalcells ThepawinmouseembryoshowingapoptosisOnedaylater,Astadpolechangesintofrog,thetailislostduetoapoptosisApoptosispathwaysAPOPTOSIS:importantinembryogenesisAPOPTOSISEvolutionarilyconservedOccursinallmulticellularanimalsstudies(plantstoo!)Stagesandgenesconservedfromnematodes(worms)andfliestomiceandhumans单击此处添加大标题内容Apoptosispathways单击此处添加大标题内容TwoPathwaysthatInitiateApoptosis?Intrinsic/MitochondrialApoptosis–RegulatedbyMitochondria–Cytochromecrelease?Extrinsic/Dea