4-Methoxyphenyl-isothiocyanate-4-Methylphenyl-ITC-生命科学试剂-MCE.pdf

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4-Methoxyphenylisothiocyanate

Cat.No.:HY-W540232

CASNo.:2284-20-0

Synonyms:4-MethylphenylITC

分⼦式:C₈H₇NOS

分⼦量:165.21

作⽤靶点:Cholinesterase(ChE)

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性4-Methoxyphenylisothiocyanate(4-MethylphenylITC)是⼀种抗氧化剂，其对DPPH⾃由基的清除能⼒表现

为IC50为1.25mM，ORAC测试显⽰其抗氧化能⼒为11.7mMTE(表⽰该化合物的抗氧化效⼒相当于11.7

mmol的Trolox(HY-101445，⼀种抗氧化剂标准品)在同样条件下的效⼒)，并在Briggs–Rauscher反应中延

长氧化过程约9180秒。同时，4-Methoxyphenylisothiocyanate具有⼀定的胆碱酯酶抑制活性，对⼄酰胆碱

酯酶(AChE)的抑制率为30.4%，对丁酰胆碱酯酶(BChE)的抑制率为17.9%。4-Methoxyphenyl

isothiocyanate有望⽤于抗氧化和神经系统疾病领域的研究[1]。

REFERENCES

[1].BurčulF,etal.Isothiocyanates:cholinesteraseinhibiting,antioxidant,andanti-inflammatoryactivity.JEnzymeInhibMedChem.2018

Dec;33(1):577-582.

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