thyroid-liu-甲状腺病理国际高峰论坛-读片会.pdf

HaiyanGu,MD

QiluHospital,ShandongUniversity(PhDstudent)

TheaffiliatedHospitalofQingdaoUniversity

ZhiyanLiu,MD,PhD

QiluHospital,ShandongUniversity

History

•43-year-oldfemalepresentedwithachief

complaintofafirmpainlessnoduleinherright

anteriorneckforalmost3weeks.Nauseaand

vomitingwerealsocomplained.

•Thethyroidultrasonographyshowedan

irregularnodulemeasuring40×23×23mm

andlymphadenopathyintherightcervix.

•Hyperthyroidismwasdemonstratedbyserum

examination.

Table1.Resultsofthyroidfunctiontests

ParametersResultsreferencerange

freetriiodothyronine(FT3)8.93pmol/l1.84.6pmol/l

↑–

freethyroxine(FT4)56.69pmol/l1222pmol/l

↑–

thyroidstimulatinghormone(TSH)0.014µIU/ml0.274.2µIU/ml

↓–

thyroglobulin(Tg)164.7ng/ml↑1.4-78ng/ml

TPOautoantibody(a-TPO)24.95IU/ml0-34IU/ml

TGautoantibody(A-TG)10.00IU/ml0-115IU/ml

β-hCG2800ug/L0.01~10.00ug/L

.

Thetumorextensivelyinvadedintothesurrounding

tissues.

Complexglandularandpapillarygrowthpatterns

Columnarcells

Discussion

Diagnosis？

•Papillarythyroidcarcinoma

•Poorlydifferentiatedcarcinoma(CyclinD1,

Bcl-2,P53,Ki-67)

•Medullarythyroidcarcinoma(calcitonin,

chromogranin)

•Metastaticendometrialcarcinoma

(TG,PAX8,TTF-1)

TTF-1TG