HL2-m5-生命科学试剂-MCE.pdf

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HL2-m5

Cat.No.:HY-P10875

CASNo.:2130846-15-8

分⼦式:C₇₀H₁₀₁N₁₅O₂₄S₃

分⼦量:1632.83

Sequence:Ac-Thr-Leu-Ser-Trp-cyclo[{O2beY}-Glu-Ala-Met-Asp-Met-Cys]-

Thr-Asp-NH2

SequenceShortening:Ac-TLSW-cyclo[{O2beY}EAMDMC]-TD-NH2

作⽤靶点:Hedgehog

作⽤通路:StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性HL2-m5是sonichedgehog/patched(Shh/PTCH1)相互作⽤的抑制剂，对Shh的Kd为170nM。HL2-m5可

抑制Hedgehog信号通路的激活和Gli控制基因的转录，IC50为230nM。

REFERENCES

[1].OwensAE,etal.,DesignandEvolutionofaMacrocyclicPeptideInhibitoroftheSonicHedgehog/PatchedInteraction.JAmChemSoc.

2017Sep13;139(36):12559-12568.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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