Emavusertib-tosylate-CA-4948-tosylate-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Emavusertibtosylate

Cat.No.:HY-135317C

CASNo.:2376399-41-4

Synonyms:CA-4948tosylate

分⼦式:C₃₁H₃₃N₇O₈S

分⼦量:663.7

作⽤靶点:IRAK;FLT3;NF-κB;MyD88;Apoptosis

作⽤通路:Immunology/Inflammation;ProteinTyrosineKinase/RTK;NF-κ

B;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Emavusertibtosylate(CA-4948tosylate)是Emavusertib(HY-135317)的甲苯磺酸盐形式。Emavusertib

tosylate是⼝服有效的IRAK4(IC50=57nM)和FLT3抑制剂。Emavusertibtosylate可抑制NF-κB和MyD88

信号通路，减少促炎细胞因⼦（如IL-6和IL-10）的产⽣，从⽽表现出抗炎和对癌细胞的抗增殖活性，诱导细

胞凋亡(apoptosis)。Emavusertibtosylate在⼩⿏模型中表现出抗肿瘤活性。

客户使⽤本产品发表的科研⽂献

•Blood.2023May12;blood.2022018718.

•FrontImmunol.09March2021.

•CurrIssuesMolBiol.2024Mar29,46(4),2946-2960.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].WieseMD,etal.InvestigationalIRAK-4inhibitorsforthetreatmentofrheumatoidarthritis.ExpertOpinInvestigDrugs.2020Apr17:1-8.

[2].GuidettiF,etal.TargetingIRAK4withEmavusertibinLymphomaModelswithSecondaryResistancetoPI3KandBTKInhibitors.JClin

Med.2023Jan4;12(2):399.

[3].ParrondoRD,etal.IRAK-4inhibition:emavusertibforthetreatmentoflymphoidandmyeloid