LH2-peptide-生命科学试剂-MCE.pdf

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LH2peptide

Cat.No.:HY-P10794

分⼦式:C₈₃H₁₂₈N₂₈O₁₇S₂

分⼦量:1854.21

Sequence:Leu-His-His-Leu-Cys-His-Leu-Leu-His-His-Leu-Cys-His-Leu-Al

a-Gly

SequenceShortening:LHHLCHLLHHLCHLAG

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LH2peptide是⼀种pH响应性的具有细胞穿透性的肽⼆聚体，其氨基酸序列为LHHLCHLLHHLCHLAG，能够

在弱酸性环境中(如肿瘤微环境)通过组氨酸残基质⼦化(pKa约为6)提⾼其在肿瘤细胞中的摄取量。LH2

peptide抗癌剂紫杉醇(HY-B0015)共轭形成PTX-LH2，在⽪下乳腺肿瘤模型中展⽰了较紫杉醇更⾼的肿瘤抑

制效果。LH2peptide有望作为递送载体⽤于抗癌领域研究[1]。

REFERENCES

[1].KimJY,etal.Combinationofpeptideswithbiological,organic,andinorganicmaterialsforsynergisticallyenhanceddiagnosticsand

therapeutics[J].PeptideScience,2022,114(3):e24233.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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