Rimegepant-sulfate-hydrate-BMS-927711-sulfate-hydrate-生命科学试剂-MCE.pdf

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Rimegepantsulfatehydrate

Cat.No.:HY-15498A

CASNo.:1374024-48-2

Synonyms:BMS-927711sulfatehydrate;BHV-3000sulfatehydrate

分⼦式:C₂₈H₂₈F₂N₆O₃.₁/₂H₂O₄S.₃/₂H₂O

分⼦量:610.26

作⽤靶点:CGRPReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Rimegepant(sulfatehydrate)是⼀种⼝服有效的、选择性的、竞争性的降钙素基因相关肽(CGRP)受体拮抗剂

，Ki为0.027nM。Rimegepant(sulfatehydrate)可⽤于偏头痛相关研究。

客户使⽤本产品发表的科研⽂献

•LancetNeurol.2022Mar;21(3):284-294.

•CellMetab.2022Nov11;S1550-4131(22)00490-9.

•AnnNeurol.2020Oct;88(4):771-784.

•BrJPharmacol.2023Aug14.

•VasculPharmacol.2017Mar;90:36-43.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].BlairHA.Rimegepant:AReviewintheAcuteTreatmentandPreventiveTreatmentofMigraine.CNSDrugs.2023Mar;37(3):255-265.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.