MAY0132-生命科学试剂-MCE.pdf

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MAY0132

Cat.No.:HY-138956

CASNo.:1895861-88-7

分⼦式:C₁₆H₁₅ClF₃N

分⼦量:313.75

作⽤靶点:NF-κB;RSV

作⽤通路:NF-κB;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MAY0132是⼀种有效的和选择性的EPAC2抑制剂，IC50为0.4μM。MAY0132能显著抑制HMPV、AdV和

RSV的复制，减少病毒感染诱导的细胞因⼦/趋化因⼦产⽣，并抑制NF-κB激活。MAY0132具有抗病毒的活

性，可⽤于呼吸道病毒感染相关研究。

IC50TargetIC50:0.4μM(EPAC2)[2]

REFERENCES

[1].ChoiEJ,etal.BroadImpactofExchangeProteinDirectlyActivatedbycAMP2(EPAC2)onRespiratoryViralInfections.Viruses.2021

Jun21;13(6):1179.

[2].WildCT,etal.FunctionalizedN,N-DiphenylaminesasPotentandSelectiveEPAC2Inhibitors.ACSMedChemLett.2016Mar

28;7(5):460-4.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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