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FerrocinA

Cat.No.:HY-N14351

CASNo.:114550-08-2

分⼦式:C₅₁H₈₂FeN₁₃O₁₉

分⼦量:1237.12

作⽤靶点:SARS-CoV;Bacterial;Antibiotic

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性FerrocinA是⼀种靶向SARS-CoV-2RNA依赖性RNA聚合酶(nsp12)的脂肽类化合物。FerrocinA可与nsp12

稳定结合，作为螯合铁的肽类，FerrocinA能通过络合作⽤降低环境中游离铁的浓度，从⽽通过抑制细菌对必

需⾦属阳离⼦的获取来抑制其⽣长。作为⼀种铁螯合型抗病毒分⼦，FerrocinA可⽤于研究新冠肺炎(COVID-

19)和细菌感染领域的研究[1]。

REFERENCES

[1].XiaB,etal.LipopeptidesagainstCOVID-19RNA-dependentRNApolymeraseusingmoleculardocking.BiomedJ.2021Dec;44(6

Suppl1):S15-S24.

[2].KatayamaN,etal.Ferrocins,newiron-containingpeptideantibioticsproducedbybacteria.Taxonomy,fermentationandbiological

activity.JAntibiot(Tokyo).1993Jan;46(1):65-70.

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