Dirozalkib-生命科学试剂-MCE.pdfVIP

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Dirozalkib

Cat.No.:HY-172426

CASNo.:1893419-37-8

分⼦式:C₂₇H₃₂ClN₅O₄S

分⼦量:558.09

作⽤靶点:Anaplasticlymphomakinase(ALK)

作⽤通路:ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Dirozalkib(Compound4)是ALK抑制剂，IC50为0.9nM。Dirozalkib在癌细胞NCI-H3122、Karpas-299和

NCI-H2228中表现出抗增殖活性，IC50分别为130.4、0.71和15.11nM。Dirozalkib表现出良好的药代动⼒

学特性，⽣物利⽤度为30%~50%[1]。

REFERENCES

[1].WuY,etal.,Polycyclicanaplasticlymphomakinaseinhibitor.WO2016050171

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