Disorazol-A-生命科学试剂-MCE.pdfVIP

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DisorazolA

Cat.No.:HY-N14734

CASNo.:158181-47-6

分⼦式:C₄₃H₅₄N₂O₁₀

分⼦量:758.9

作⽤靶点:Microtubule/Tubulin;Apoptosis;Fungal

作⽤通路:CellCycle/DNADamage;Cytoskeleton;Apoptosis;Anti-

infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DisorazolA1是⼀种tubulin抑制剂，具有抗真菌活性。DisorazolA1的作⽤是抑制微管蛋⽩聚合，⼲扰微管

形成，阻断有丝分裂，从⽽使细胞周期阻滞在G2/M期，诱导凋亡(apoptosis)。DisorazolA1对L929⼩⿏成

纤维细胞也表现出抑制作⽤，IC50值为3pm。DisorazolA1引起细胞核中p53蛋⽩的积累。DisorazolA1有

望⽤于癌症研究[1]。

REFERENCES

[1].ElnakadyYA,etal.DisorazolA1,ahighlyeffectiveantimitoticagentactingontubulinpolymerizationandinducingapoptosisin

mammaliancells.BiochemPharmacol.2004Mar1;67(5):927-35.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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