糖尿病患者接种SARS-Cov-2疫苗后的免疫反应：系统评价.docx

糖尿病患者接种SARS-Cov-2疫苗后的免疫反应：系统评价

王婧刘艳陈雅菲苗茂华

[关键词]?SARS-CoV-2?疫苗；体液免疫；细胞免疫；糖尿病

[中图分类号]?R186??????[文献标识码]?A??????[DOI]?10.3969/j.issn.1673-9701.2024.06.002

Immune?response?of?diabetes?patients?after?receiving?SARS-Cov-2?vaccine：?A?systematic?review

WANG?Jing1，?LIU?Yan1，?CHEN?Yafei2，?MIAO?Maohua2

1.Department?of?Immunization?and?Prevention，?Hangzhou?Center?for?Disease?Control?and?Prevention，?Hangzhou?310021，?Zhejiang，?China;?2.Department?of?Public?Health?and?Policy?Research，?Shanghai?Institute?of?Biomedical?and?Pharmaceutical?Technologies，?Shanghai?200237，?China

[Abstract]?Objective?To?evaluate?the?efficacy?of?SARS-CoV-2?vaccines?in?diabetic?patients?through?a?systematic?review.?Methods?PubMed，?Web?of?Science，?CNKI，?WanFang?Data，?CQVIP，?and?SinoMed?databases?were?searched?to?identify?observational?studies?which?reported?the?humoral?or?cellular?responses?of?SARS-CoV-2?vaccines?in?diabetic?patients?between?December?1，?2019?to?May?12，?2022.?Two?reviewers?independently?implemented?literature?screening?and?data?extraction，?and?used?the?National?Institute?of?Health?Study?Quality?Assessment?Tool?to?evaluate?the?methodological?quality?of?the?included?studies.?Results?Thirteen?studies?with?a?total?of?66?651?subjects?were?identified，?and?5874?（7.9%）?of?them?had?diabetes.?Immune?responses?against?SARS-CoV-2?were?increased?after?the?vaccines?in?both?diabetic?patients?and?controls.?Among?the?7?studies?that?reported?the?immune?response?of?diabetic?patients?after?1?dose?of?vaccine，?3?literatures?showed?that?the?antibody?levels?and?seropositivity?rates?of?diabetic?patients?were?lower?than?those?of?control?group;?Among?the?11?studies?that?reported?the?immune?responses?after?2?doses?of?SARS-CoV-2?vaccines，?2?studies?reported?that?diabetic?patients?could?produce?antibody?levels?comparable?to?those?in?controls，?and?9?studies?showed?that?antibody?levels，?seropositivity?rates?or?cellular?immune?response?were?lower?than?those?of?the?control?group.?Conclusion?The?humoral?and?cellular?immu