SMW139-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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SMW139

Cat.No.:HY-171462

CASNo.:2133010-38-3

分⼦式:C₁₉H₂₁ClF₃NO₂

分⼦量:387.82

作⽤靶点:P2XReceptor;InterleukinRelated

作⽤通路:MembraneTransporter/IonChannel;

Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SMW139是P2X7受体的选择性变构拮抗剂，对⼈P2X7R的Ki值为32nM。SMW139在⼤⿏肝微粒体中的半

衰期为47分钟。SMW139可⽤于研究炎症、阿尔茨海默病和多发性硬化症[1]。

REFERENCES

[1].JanssenB,etal.IdentificationoftheallostericP2X7receptorantagonist[11C]SMW139asaPETtracerofmicroglialactivation.SciRep.

2018Apr26;8(1):6580.

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