Adenosine-5-diphosphoribose-sodium-Standard-ADP-ribose-sodium-Standard-生命科学试剂-MCE.pdf

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Adenosine5′-diphosphoribosesodium(Standard)

Cat.No.:HY-100973AR

CASNo.:68414-18-6

Synonyms:ADPribosesodium(Standard)

分⼦式:C₁₅H₂₂N₅NaO₁₄P₂

分⼦量:581.3

作⽤靶点:TRPChannel;Autophagy

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling;

Autophagy

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Adenosine5′-diphosphoribose(sodium)(Standard)是Adenosine5′-diphosphoribose(sodium)的分析

标准品。本产品⽤于研究及分析应⽤。Adenosine5′-diphosphoribosesodium(ADPribosesodium)是⼀种

烟酰胺腺嘌呤核苷酸(NAD+)的代谢产物，也是⼀种最有效和最主要的细胞内Ca2+渗透性阳离⼦TRPM2通道

激活剂，还可以增强⾃噬(autophagy)。

IC50TargetTRPM2channel[1][2]

Autophagy[1]

REFERENCES

[1].ZhangDX,etal.ThepotentialregulatoryrolesofNAD(+)anditsmetabolisminautophagy.Metabolism.2016Apr;65(4):454-62.

[2].TóthB,etal.PorecollapseunderliesirreversibleinactivationofTRPM2cationchannelcurrents.ProcNatlAcadSciUSA.2012Aug

14;109(33):13440-5.

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