Glyceryl-monostearate-d5-GMS-d-sub-5-sub-生命科学试剂-MCE.pdfVIP

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Glycerylmonostearate-d5

Cat.No.:HY-W704076

CASNo.:1432065-28-5

Synonyms:GMS-d5

分⼦式:C₂₁H₃₇D₅O₄

分⼦量:363.59

作⽤靶点:Isotope-LabeledCompounds;Liposome

作⽤通路:Others;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Glycerylmonostearate-d5(GMS-d5)是氘代标记的Glycerylmonostearate.Glycerylmonostearate(GMS)是

⼀种单尾脂质单⽢油酯，可⽤于合成⽤于药物递送的纳⽶脂质体。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].MeghaMarwah,etal.GlycerylMonostearate:ProbingtheSelfAssemblyofaLipidAmenableToSurfaceModificationforHepatic