Cypermethrin-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Cypermethrin

Cat.No.:HY-B0829

CASNo.:52315-07-8

分⼦式:C₂₂H₁₉Cl₂NO₃

分⼦量:416.3

作⽤靶点:SodiumChannel;ChlorideChannel;PotassiumChannel;

CalciumChannel;nAChR

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Cypermethrin是⼀种可穿透⾎脑屏障(BBB)的II类拟除⾍菊酯类农药。Cypermethrin具有神经毒性，并会导

致运动功能障碍。Cypermethrin会延长(钠离⼦通道)的开放时间，使中枢神经系统过度兴奋。通过调节(氯离

⼦通道)、(钙离⼦通道)和(钾离⼦通道)，并影响⾕氨酸受体和⼄酰胆碱受体，Cypermethrin会在神经元中引

发DNA损伤和氧化应激。此外，Cypermethrin还会调节γ-氨基丁酸和多巴胺等神经递质的⽔平。

REFERENCES

[1].SinghAK,etal.Acurrentreviewofcypermethrin-inducedneurotoxicityandnigrostriataldopaminergicneurodegeneration.Curr

Neuropharmacol.2012Mar;10(1):64-71.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedCh