Beraprost-d3-TRK-100-d-sub-3-sub-生命科学试剂-MCE.pdfVIP

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Beraprost-d3

Cat.No.:HY-166363S

Synonyms:TRK-100-d;ML1129-d

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分⼦式:C₂₄H₂₇D₃O₅

分⼦量:401.51

作⽤靶点:Isotope-LabeledCompounds;ProstaglandinReceptor

作⽤通路:Others;GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Beraprost-d3(TRK-100-d3)是氘代标记的(Rac)-Beraprost.(Rac)-Beraprost((Rac)-ML1229)是⼀种具有⼝服

活性的前列环素类似物，通过与前列环素膜受体(ProstaglandinReceptor)结合来抑制Ca2+从细胞内储存位

点释放，从⽽导致平滑肌细胞松弛和⾎管舒张。Beraprost具有促⾎管扩张，抗⾎⼩板和细胞保护作⽤，有望

⽤于⼼⾎管疾病领域研究，如⾎栓闭塞性脉管炎和闭塞性动脉硬化[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthe