allergy and risk of meta-analysisglioma荟萃分析过敏风险.pdfVIP

EuropeanJournalofNeurology2011,18:387–395doi:10.1111/j.1468-1331.2010.03187.x

REVIEWARTICLE

Allergyandriskofglioma:ameta-analysis

a,a,aaaab

C.Chen*,T.Xu*,J.Chen,J.Zhou,Y.Yan,Y.LuandS.Wu

aDepartmentofNeurosurgery,ChangzhengHospital,SecondMilitaryMedicalUniversity,Shanghai,;andbDivisionofHematology

andOncology,DepartmentofMedicine,StonyBrookUniversityCancerCenter,NewYork,NY,USA

Keywords:Weevaluatedtheassociationbetweenallergicconditionsandtheriskofgliomain

allergy,glioma,meta-case–controlandcohortstudiespublishedsofaronthisissue.Atotalof12studies(10

analysis,riskfactorcase–controland2cohortstudies)wereincludedintheanalysis,involving61090

participants,ofwhom6408hadglioma.Whencomparedwithnon-allergicconditions,

Received11April2010thepooledoddsratio(OR)withanyallergicconditionsforgliomawas0.60(95%CI:

Accepted8July20100.52–0.69,P0.001),suggestingasignificantnegativeassociation(protectiveeffect)

betweenallergyandglioma.SubgroupanalysisshowedthattheORswere0.70(95%

CI:0.62–0.79,P0.001),0.69(95%CI:0.62–0.78,P0.001),and0.78(95%CI:

0.70–0.87,P0.001)forasthma,eczema,andhayfever,respectively.Thesignificant

associationremainedevenafterexcludingthebiasofreporting(OR0.61;

95%CI:0.50–0.75,P0.001).Weconcludethatallergi