SDH-IN-25-生命科学试剂-MCE.pdfVIP

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SDH-IN-25

Cat.No.:HY-172777

CASNo.:3052432-15-9

分⼦式:C₁₉H₁₅BrCl₂N₂O₄

分⼦量:486.14

作⽤靶点:SuccinateDehydrogenase;Fungal;ReactiveOxygenSpecies;

MMP

作⽤通路:MetabolicEnzyme/Protease;Anti-infection;

Immunology/Inflammation;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SDH-IN-25是⼀种SDH抑制剂(IC50=4.82mg/L)。SDH-IN-25具有⼴谱强效的抗真菌活性。SDH-IN-25通过

与SDH氨基酸残基(TRP173、TYR58和ARG43)结合，模拟了市售杀菌剂氟唑菌酰胺(HY-135549)的作⽤模

式。SDH-IN-25可以诱导菌丝形态，通过与复合物II结合⼲扰呼吸代谢，产⽣活性氧(ROS)，并影响菌丝体中

的线粒体膜电位(MMP)。SDH-IN-25可⽤于农业病害防治研究[1]。

体外研究SDH-IN-25(Compound7IIj)(0-20mg/L)demonstratesexcellentandbroad-spectrumfungicidaleffects

against8phytopathogenicstrainsincludingR.solani(EC50=0.179mg/L),P.piricola(EC50=0.301mg/L),

S.sclerotiorum(EC50=3.47mg/L),V.mali(EC50=0.789mg/L),F.graminearum(EC50=6.29mg/L),B.

cinerea(EC50=0.647mg/L),P.capsici(EC50=5.78mg/L),andG.graminis(EC50=0.549mg/L)[1].

SDH-IN-25(5-20mg/L,1-9h)resultsintheinhibitionofrespiratorymetabolismofR.solani[1].