参考学习资料生物学习 1_pnas.2113454119.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

TRIM14inhibitsOPTN-mediatedautophagic

degradationofKDM4Dtoepigeneticallyregulate

inﬂammation

a,1a,b,1a,1aaaa,2

DiLiu,ZhiyaoZhao,YuanchuShe,LeiZhang,XiangtianChen,LingMa,andJunCui

aGuangdongProvinceKeyLaboratoryofPharmaceuticalFunctionalGenes,MOEKeyLaboratoryofGeneFunctionandRegulation,StateKeyLaboratoryof

Biocontrol,SchoolofLifeSciences,SunYat-senUniversity,Guangdong510275,People’sRepublicofChina;andbDepartmentofInternalMedicine,Guangzhou

InstituteofPediatrics,GuangzhouWomenandChildren’sMedicalCenter,Guangdong510623,People’sRepublicofChina

EditedbyNoboruMizushima,DepartmentofBiochemistryandMolecularBiology,UniversityofTokyo,GraduateSchoolandFacultyofMedicine,Tokyo,

Japan;receivedJuly21,2021;acceptedJanuary5,2022byEditorialBoardMemberTadatsuguTaniguchi

Autophagyisafundamentalcellularprocessofproteindegrada-membranebindingofCD14toprimarymacrophages(16).

tionandrecyclingthatregulatesimmunesignalingpathwaysviaLysinedemethylase5A(KDM5A)removesH3K4me3modiﬁ-

multiplemechanisms.However,itremainsunclearhowautophagycationattheSocs1promotertoinhibittheexpressionof

epigeneticallyregulatestheimmuneresponse.Here,weidentiﬁedsuppressorofcytokinesignaling1(SOCS1),leadingtosignal

TRIM14asanepigeneticregulatorthatreduceshistoneH3K9tri-transducerandactivatoroftranscription4(STAT4)activation

methylati

该用户很懒，什么也没介绍

咨询Ta 进入空间

更多 >

参考学习资料 生物学习 1_pnas.2113454119.pdf