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- 2025-08-21 发布于广东
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*足细胞(podocyte)有初、次级突起,其次级突起间相互嵌合为栅栏状,之间有裂孔,上有裂孔膜。第30页,共50页,星期日,2025年,2月5日③滤过膜filtrationmembrane又称滤过屏障filtrationbarrier,由有孔毛细血管内皮、基膜和足细胞裂孔膜构成。第31页,共50页,星期日,2025年,2月5日滤过屏障模式图返回第32页,共50页,星期日,2025年,2月5日diffuselythickenedcapillary
wallsandmildendocapillaryproliferationCellularcrescents第33页,共50页,星期日,2025年,2月5日(arrows)tubularatrophyandinterstitialinflammationfragmentedredcellsTheGBMwasmarkedlythickened,impartinga“wireloop”appearance白金耳第34页,共50页,星期日,2025年,2月5日abundantgranularimmune-complexdepositioninthemesangiumandalongtheglomerularbasementmembraneinaclassic“fullhouse”pattern满堂亮(anti-IgGimmunofluorescence)Immunecomplexdepositionisalsoseenalongthetubularbasementmembrane第35页,共50页,星期日,2025年,2月5日abundantelectron-densedepositsareseeninamesangial,intramembranous,subepithelial,andsubendothelialdistribution第36页,共50页,星期日,2025年,2月5日第1页,共50页,星期日,2025年,2月5日
A35-year-oldmanwithdyspnea,anemia,andrenalfailure第2页,共50页,星期日,2025年,2月5日severalweeksago,thepatientfeltfatigue.Twodaysbeforeadmission,dyspneadeveloped,decreasedurination,withoutfever,cough,orchestpain,nohemoptysis咯血,chills,nightsweats,headaches,visualloss,dryeyes,drymouth,orjointpain.Hewastransferredbyambulancetotheemergencydepartmentatthishospital第3页,共50页,星期日,2025年,2月5日Fouryearsbeforeadmission,hehadbeenevaluatedbecauseofbackpain,fatigue,andatemperatureof38.6°C.Urinalysisshowedhematuria血尿andproteinuria;testingforrapidplasmareagin(RPR快速血浆反应素)waspositiveforantibodiestoTreponemapallidum(梅毒螺旋体).Duringtheprevious6months,thepatienthadhadepisodesofbilateralfinger,ankle,andfacialswelling,withoutpainorchangeincolor.Hehadnohistoryofrecenttravel,exposuretosickpersons,bloodtransfusions,orprevioussurgery.Hedidnotsmoke,drinkalcohol,oruseillicitdrugs.第4页,共50页,星期
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