MAO-B-IN-44-生命科学试剂-MCE.pdfVIP

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MAO-B-IN-44

Cat.No.:HY-174834

CASNo.:1454707-25-5

分⼦式:C₃₄H₃₂N₄O₈

分⼦量:624.64

作⽤靶点:MonoamineOxidase

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MAO-B-IN-44(Compound4n)是⼀种单胺氧化酶B(MAO-B)的选择性抑制剂，IC50为1.01μM，对MAO-A

抑制较弱(IC50=14.4μM)。MAO-B-IN-44减少多巴胺等神经递质降解。MAO-B-IN-44有望⽤于帕⾦森病等与

MAO-B异常相关的神经退⾏性疾病的研究。

IC50TargetMAO-AMAO-B

14.4μM(IC50)1.01μM(IC50)

REFERENCES

[1].KhanOR,etal.Design,Synthesis,BiologicalEvaluation,andInSilicoStudyofTetrahydropyridinesasProspectiveMonoamine

OxidaseInhibitors[J].ChemistryOpen,e202400516.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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