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MAO-B-IN-45

Cat.No.:HY-176271

CASNo.:3069915-36-9

分⼦式:C₁₇H₁₄ClNO₃

分⼦量:315.75

作⽤靶点:Ferroptosis;MonoamineOxidase;GlutathionePeroxidase;

ReactiveOxygenSpecies(ROS);TauProtein;Amyloid-β

作⽤通路:Apoptosis;NeuronalSignaling;MetabolicEnzyme/Protease;

Immunology/Inflammation;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MAO-B-IN-45是⼀种铁死亡(ferroptosis)和MAO-B的双重抑制剂。MAO-B-IN-45对MAO-B具有选择性，

IC50为87.47nM，对MAO-B的选择性⽐MAO-A⾼229倍以上。MAO-B-IN-45在体外通过调节铁代谢途径

和GSH-GPX4轴表现出卓越的抗铁死亡活性。MAO-B-IN-45能改善3×Tg(APP/Tau/Ps1)阿尔茨海默病⼩⿏的

认知和⾏为障碍，并显著降低其脑内铁蛋⽩重链1(FTH1)、β-淀粉样蛋⽩(APP)和Tau蛋⽩磷酸化(p-Tau)的

⽔平[1]。

IC50TargethMAO-B

87.47nM(IC50)

体外研究MAO-B-IN-45(compound21d)isareversiblehMAO-BinhibitorwithinhibitionconstantaKivalueof100.6

nM,whichdisplayshighhMAO-Binhibitoryactivity,andtheinhibitionrateare94.81%(10μM)and76.31%

(1μM)[1].MAO-B-IN-45(0.1-75μM,24h)showsfavorablesafetyinPC12cellsandHT22cells[1].MAO-B-IN-

45(1-50μM,24h)effectivelymitigatesferroptosisinducedby