硅胶负载催化剂合成α-氨基腈研究.pdfVIP

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ChemicalLetters23(2012)1103–1106

Synthesisofa-aminonitriusingsilica-bondedN-propylpiperazine

sulfamicacidasarecyclablecatalyst

aab,

TahereRahi,MojtabaBaghernejad,KhodabakhshNiknam*

aDepartmentofChemistry,GachsaranBranch,cAzadUniversity,Gachsaran,Iran

bDepartmentofChemistry,FacultyofSciences,PersianGulfUniversity,Bushehr75169,Iran

Received11April2012

Availableonline23September2012

a-Aminonitriweresynthesizedviaaone-potthree-componentcondensationofaldehydes,amines,andtrimethylsilylcyanide

usingsilica-bondedN-propylpiperazinesulfamicacid(SBPPSA)asarecyclablesolidacidatroomtemperature.SBPPSAshowed

muchthesameefficiencywhenusedinconsecutivereactionruns.

#2012KhodabakhshNiknam.PublishedbyElsevierB.V.onbehalfofChemicalSociety.Allrights.

Keywords:Silica-bondedN-propylpiperazinesulfamicacid;a-Aminonitri;Aldehydes;Amines;Catalyst;Solidacid

Theadditionofcyanideaniontoimines(theStreckerreaction)[1]providesoneofthemostimportantand

straightforwardmethodforthesynthesisofa-aminonitri,whichareusefulintermediatesforthesynthesisofamino

acids[2]andnitrogencontaininghetero