RP-220-生命科学试剂-MCE.pdfVIP

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RP-220

Cat.No.:HY-P6084

CASNo.:1541177-35-8

分⼦式:C₉₈H₁₆₆N₃₀O₃₂S

分⼦量:2308.61

Sequence:Cys-Ile-Arg-Phe-Val-Ser-Ile-Asp-Asn-Lys-Lys-Arg-Asn-Ile-Glu-

Ser-Ser-Glu-Ile-Gly

SequenceShortening:CIRFVSIDNKKRNIESSEIG

作⽤靶点:NOD-likeReceptor(NLR);p38MAPK;Apoptosis

作⽤通路:Immunology/Inflammation;MAPK/ERKPathway;Apoptosis

储存⽅式:Sealedstorage,awayfrommoisture

Powder-80°C2years

-20°C1year

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性RP-220是⼀种靶向NLRP3的肾素酶肽。RP220具有抗炎和抗凋亡活性。RP220通过激活MAPK信号通路抑制

碱性损伤引起的肾⼩管上⽪细胞凋亡(apoptosis)。RP220显著抑制急性肾损伤(AKI)⼩⿏模型中NLRP3表达

，并减少巨噬细胞浸润和肾脏组织损伤。RP-220可⽤于系统性红斑狼疮(SLE)及其并发症狼疮性肾炎(LN)研

究[1]。

IC50TargetNLRP3

REFERENCES

[1].WangL,etal.ApplicationofrenalaminerelatedactivepolypeptideRP220inpreparationofmedicinefortreatingkidneydiseases.

CN110772634A.2020-02-11.

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