1-4-Naphthoquinone-NH-C2-NH-Trolox-生命科学试剂-MCE.pdfVIP

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1,4-Naphthoquinone-NH-C2-NH-Trolox

Cat.No.:HY-175823

分⼦式:C₂₆H₂₈N₂O₅

分⼦量:448.51

作⽤靶点:Ferroptosis;ReactiveOxygenSpecies(ROS)

作⽤通路:Apoptosis;Immunology/Inflammation;Metabolic

Enzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性1,4-Naphthoquinone-NH-C2-NH-Trolox是⼀种具有神经保护活性的可穿透⾎脑屏障的Trolox(HY-101445)和

维⽣素K(HY-B2172)的结合物。1,4-Naphthoquinone-NH-C2-NH-Trolox能够抑制氧化死亡(oxytosis)、铁死

亡(ferroptosis)、ATP耗竭以及活性氧(ROS)的产⽣。1,4-Naphthoquinone-NH-C2-NH-Trolox可选择性抑制

M1标志物的表达。1,4-Naphthoquinone-NH-C2-NH-Trolox可⽤于神经系统疾病的研究，如阿尔茨海默病(

AD)[1]。

体外研究1,4-Naphthoquinone-NH-C2-NH-Trolox(Compound16e)exhibitspotentandcomparableradicalscavenging

activitywithanEC50of15.4μM[1].

1,4-Naphthoquinone-NH-C2-NH-Trolox(0.38-25μM,24h)inhibitoxytosis,ferroptosis,andATPdepletionin

HT22hippocampalnervecells[1].

1,4-Naphthoquinone-NH-C2-NH-Trolox(0.4μM,8h)reducesROSproductioninHT22cells[1].

1,4-Naphthoquinone-NH-C2-NH-Trolox(0.5-2.5μM,24h)selectivesuppressesM1markersinHT22cells