USP30-IN-20-生命科学试剂-MCE.pdfVIP

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USP30-IN-20

Cat.No.:HY-175826

分⼦式:C₁₆H₁₅ClO₂S

分⼦量:353.7

作⽤靶点:Deubiquitinase;Ferroptosis;ReactiveOxygenSpecies(ROS);

GlutathionePeroxidase

作⽤通路:CellCycle/DNADamage;Apoptosis;

Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性USP30-IN-20是⼀种具有⼝服活性的USP30抑制剂(Kd=1.61μM，IC50=12.8μM)。USP30-IN-20通过促

进GPX4的泛素化介导降解诱导铁死亡(ferroptosis)。USP30-IN-20抑制前列腺癌细胞的增殖、迁移、侵袭能

⼒。USP30-IN-20诱导前列腺癌细胞的G0/G1期阻滞并升⾼ROS⽔平。USP30-IN-20在⼩⿏PC3细胞⽪下异

种移植模型中显⽰出显著抗肿瘤活性。USP30-IN-20可⽤于晚期前列腺癌研究[1]。

IC50TargetUSP30USP30

1.61μM(Kd)12.8μM(IC50)

体外研究USP30-IN-20(Compound8m)showspotentanti-proliferativeactivityagainstPC3,DU145prostatecancer

cells,andCD24-CD44+prostatecancerstem-likecells,withIC50valuesof4.87μM,5.44μM,and5.94μM,

respectively[1].

USP30-IN-20(2.5-5μM,14days)significantlyreducesthenumberofmalignantcoloniesofPC3andDU145