Tubulin-CDC5L-IN-1-生命科学试剂-MCE.pdfVIP

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Tubulin/CDC5L-IN-1

Cat.No.:HY-175713

分⼦式:C₂₈H₃₂N₆O₈

分⼦量:580.59

作⽤靶点:Microtubule/Tubulin;Apoptosis;ReactiveOxygenSpecies

(ROS)

作⽤通路:CellCycle/DNADamage;Cytoskeleton;Apoptosis;

Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Tubulin/CDC5L-IN-1是⼀种Tubulin/CDC5L双重抑制剂。Tubulin/CDC5L-IN-1靶向CDCL5，其KD值为

103.7μM。Tubulin/CDC5L-IN-1能够抑制多种癌细胞的增殖，并诱导G2/M期阻滞。Tubulin/CDC5L-IN-1可

诱导细胞凋亡(apoptosis)和活性氧(ROS)产⽣。Tubulin/CDC5L-IN-1具有抗⾎管⽣成作⽤。Tubulin/CDC5L-

IN-1可⽤于癌症研究，如结肠癌[1]。

体外研究Tubulin/CDC5L-IN-1(Compound11i)(48h)inhibitsHeLa,HCT116,A2780,andA549cellsproliferationwith

IC50valuesof0.046,0.035,0.096and0.112μM[1].

Tubulin/CDC5L-IN-1showsantiproliferativeefficacyindrug-resistantcancercellswithIC50rangingfrom

0.089-0.172μM[1].

Tubulin/CDC5L-IN-1(1-100μM,0-30mins)inhibitsthemicrotubuleassemblywithanIC50of28.8μM[1].

Tubulin/CDC5L-IN-1(0.125-0.05μM,24h)inhibitscolonyformationinHeLaandHCT116cells[1].