LW106-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

LW106

Cat.No.:HY-134920

CASNo.:2116519-76-5

分⼦式:C₁₁H₁₁N₅O₂

分⼦量:245.24

作⽤靶点:Indoleamine2,3-Dioxygenase(IDO);Apoptosis;SWI/SNF

Complex

作⽤通路:MetabolicEnzyme/Protease;Apoptosis;CellCycle/DNA

Damage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LW106是⼀种选择性IDO1抑制剂，IC50为1.57μM。LW106对IDO2和TDO⽆抑制作⽤。LW106通过限

制基质免疫串扰和肿瘤微环境中的肿瘤⼲细胞(CSC)富集来抑制肿瘤⽣长。LW106可减少异种移植肿瘤中的肿

瘤⼲细胞(CSC)亚群，导致肿瘤细胞增殖/侵袭性降低，并诱导肿瘤细胞凋亡(apoptosis)。LW106可⽤于肺癌

和⿊⾊素瘤的研究[1]。

IC50TargetIDO1

1.57μM(IC50)

体外研究LW106(12.5-200μM)doesnotaffectproliferationofthreetypesoftumorcells(HeLa,Lewis,B16F10cells)

withdifferentexpressionlevelsofIDO1[1].

LW106restoresthefunctionofCD8+TcellsbyblockingtheactivityofIDO1[1].

体内研究LW106(20-80mg/kg,i.p.,oncedailyfor18days)inhibitstumorgrowthofLewislungcancerorB16F10

melanomaanditsanti-tumoreffectreliesonT-cellimmunityandhost-derivedIDO1[1].

AnimalModel:LewisandB16F10tumorsmodelestablishedin57BL6mice,athymicnudemiceorId