（27）CHO 细胞中的重组治疗性蛋白降解和克服策略.pdfVIP

AppliedMicrobiologyandBiotechnology(2024)108:182

/10.1007/s00253-024-13008-6

MINI-REVIEW

Recombinanttherapeuticproteinsdegradationand

overcoming

strategiesin

CHOcells

1,2,341,41,21,2,31,2,3

Shao‑Lei

Geng

·Xiao‑Jie

Zhao

·Xi

Zhang

·Ji‑Hong

Zhang

·Chun‑Liu

Mi

·Tian‑Yun

Wang

Received:6November2023/Revised:20December2023/Accepted:8January2024

©TheAuthor(s)2024

Abstract

Mammaliancelllinesarefrequentlyusedas