3-Hydroxykynurenine-13C2-15N-hydrochloride-3-Hydroxy-DL-kynurenine-sup-13-sup-C-sub-2-sub-sup-15-sup-N-hydrochloride-生命科学试剂-MCE.pdfVIP

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3-Hydroxykynurenine-13C2,15Nhydrochloride

Cat.No.:HY-113294S2

Synonyms:3-Hydroxy-DL-kynurenine-13C,15Nhydrochloride

2

分⼦式:C₈₁₃C₂H₁₂N₁₅NO₄.xHCl

作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite;

Apoptosis

作⽤通路:Others;MetabolicEnzyme/Protease;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性3-Hydroxykynurenine-13C2,15N(3-Hydroxy-DL-kynurenine-13C2,15N)hydrochloride是13C和15N标记的

3-Hydroxykynureninehydrochloride(HY-113294)。3-Hydroxykynurenine是⾊氨酸的代谢产物，是⼀种潜

在的内源性神经毒素，其⽔平在多种神经退⾏性疾病中有所增加。3-Hydroxykynurenine诱导神经元凋亡(

apoptosis)。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs