mNLS-CPP-WSTF-TFA-生命科学试剂-MCE.pdfVIP

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mNLS-CPP-WSTFTFA

Cat.No.:HY-P11208C

分⼦式:C₂₁₉H₃₆₁N₆₉O₆₄.xC₂HF₃O₂

Sequence:Glu-Glu-Glu-Ala-Ala-Gly-Arg-Lys-Arg-Lys-Lys-Arg-Thr-Ser-Ser-

Gly-Lys-Pro-His-Lys-His-Leu-Pro-Pro-Ala-Ala-Leu-His-Leu-Ile-Al

a-Tyr-Tyr-Lys-Glu-Asn-Lys-Asp-Lys-Glu-Asp-Lys-Lys

SequenceEEEAAGRKRKKRTSSGKPHKHLPPAALHLIAYYKENKDKEDKK

Shortening:

作⽤靶点:GABAReceptor

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling

储存⽅式:Sealedstorage,awayfrommoisture

Powder-80°C2years

-20°C1year

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性mNLS-CPP-WSTFTFA是mNLS-CPP-WSTF(HY-P11208)的三氟⼄酸盐。mNLS-CPP-WSTF是⼀种基于⼩⿏

WSTF序列的核定位信号(NLS)-细胞穿透肽。mNLS-CPP-WSTF显著抑制GABARAP-WSTF相互作⽤，WSTF降

解和炎症基因表达。mNLS-CPP-WSTF有效缓解代谢功能障碍相关脂肪性肝炎(MASH)和⾻关节炎(OA)⼩⿏模

型中的慢性炎症、肝纤维化和软⾻损伤。mNLS-CPP-WSTF具有MASH和OA等慢性炎症性疾病的研究潜⼒

[1]。

REFERENCES

[1].WangY,etal.WSTFnuclearautophagyregulateschronicbutnotacuteinfl