PI3Kα-IN-28-生命科学试剂-MCE.pdfVIP

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PI3Kα-IN-28

Cat.No.:HY-178984

CASNo.:3095278-75-1

分⼦式:C₅₁H₅₁ClF₂N₁₀O₅S₂

分⼦量:1021.59

作⽤靶点:PI3K;EpigeneticReaderDomain;DNA/RNASynthesis;Akt;c-

Myc;AMPK

作⽤通路:PI3K/Akt/mTOR;Epigenetics;CellCycle/DNADamage;

Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PI3Kα-IN-28是⼀种⾼效的PI3K/BRD4双靶点抑制剂。PI3Kα-IN-28可以抑制多种细胞的增殖，如KYSE180

(IC50=1.46µM)、KYSE450(IC50=0.57µM)细胞。PI3Kα-IN-28可以浓度依赖性抑制迁移和克隆形成，诱导

G0/G1期阻滞，显著抑制DNA合成(DNAsynthesis)并显著增加衰⽼细胞⽐例。PI3Kα-IN-28能抑制p-AKT

和c-Myc表达并激活AMPK-p27通路。PI3Kα-IN-28可以⽤于癌症如⾷管癌的研究[1]。

IC50TargetPI3KαBRD4

REFERENCES

[1].PengS,etal.DiscoveryofNovelPI3K/BRD4DualInhibitorsforEsophagealCancer:RationalDesign,Optimization,andSenescence-

InducingMechanisms.JMedChem.2025Oct20.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.