关于抗Aβ单克隆抗体的临床应用建议（2024版）.pdfVIP

·120·中国现代神经疾病杂志2024年3月第24卷第3期ChinJContempNeurolNeurosurg,March2024,Vol.24,No.3

·标准与指南·

关于抗Aβ单克隆抗体的临床应用建议（2024版）

王刚李彬寅任汝静肖金雯陈生弟陈晓春

【摘要】最新研发的抗Aβ单克隆抗体陆续在国内外获批上市，并逐渐应用于我国临床实践。为促

进抗Aβ单克隆抗体在我国阿尔茨海默病治疗中更合理、安全的应用，本文结合抗Aβ单克隆抗体现有临

床试验证据及阿杜卡单抗在上海交通大学医学院附属瑞金医院海南医院的临床应用经验，总结抗Aβ单

克隆抗体的临床应用建议，包括临床用药指征、用药前评估及准备、用药时医嘱及注意事项、用药后临床

监测，旨在为临床医师提供翔实的用药指导和建议。

【关键词】阿尔茨海默病；淀粉样β肽类；抗体，单克隆；诊疗指南；综述

Recommendationsfortheclinicaluseofanti⁃Aβmonoclonalantibodyfor

Alzheimersdisease(2024)

111112

WANGGang,LIBin‑yin,RENRu‑jing,XIAOJin‑wen,CHENSheng‑di,CHENXiao‑chun

1DepartmentofNeurology,RuijinHospital,ShanghaiJiaotongUniversitySchoolofMedicine,

Shanghai200025,China

2DepartmentofNeurology,FujianMedicalUniversityUnionHospital,Fuzhou350001,Fujian,China

Correspondingauthors:CHENSheng⁃di(Email:chensd@);

CHENXiao⁃chun(Email:chenxc998163.com)

【Abstract】Severalanti‑Aβmonoclonalantibodydrugshavebeenapprovedforclinicaluseathome

andabroadrecently.Inordertofacilitateitssafeandeffectivetreatmentofanti‑Aβmonoclonalantibody

drugsforAlzheimer′sdisease(AD)inChina,wepresentrecommendationsfortheclinicaluseofanti‑Aβ

monoclonalantibodydrugsbasedonexistingclinicaltrialsandtheclinicalpracticeofADtreatmentwith

AducanumabatRuijinHospitalHainanBranch,ShanghaiJiaotongUniversitySchoolofMedicine.The

recommendationsincludeclinicalindications,pre‑medicationassessmentandpreparation,medication

instructionsandprecautions,aswellaspost‑medicationclinicalmonitoring,whichisaimedtofurnish

clinicianswithcomprehensivemedicationguidance.

【Keywords】Alzheimerdisease;Amyloidbeta‑peptides;Antibodies,monoclonal;Diagnostic

andtreatmentguideline;Review

ThisstudywassupportedbyagrantfromSTI2