11原发性支气管肺癌(中英文对照2008).pptVIP

原发性支气管肺癌

Primarybronchogeniccarcinoma呼吸内科RespiratoryDepartment熊维宁Xiong,Weining1

定义

Definition原发性支气管肺癌简称肺癌，是起源于支气管粘膜或腺体的肿瘤。Primarybronchogeniccarcinomaisabbreviatedtolungcancer,itderivesfrombronchimucosaorgland.2

EpidemiologyLungCancerWorldwide:mostcommoncancer2,000,000casesperyearChina:firstleadingcauseofcancerdeathinurbanarea15%5-yearsurvival3

病因和发病机制

Etiologyandpathogenesis1吸烟1Smoking4

LungCancer:SmokingFactsTobaccouseistheleadingcauseoflungcancer87%oflungcancersarerelatedtosmokingRiskrelatedto:AmountsmokedAgeofsmokingonsetProductsmoked(tar/nicotinecontent,filters)DepthofinhalationGenderRiskgoesdownafter5yrscessationAt15years,80-90%riskreductionNevergetsto“neversmoker”risk5

20YearLag6

Ifwhathappenedonyourinsidehappenedonyouroutside,wouldyoustillsmoke?7

2职业致癌因子2Occupationcarcinogenicfactor:Asbestos,Radon3空气污染3Airpollution（1）室外大环境污染（1）Outdoorenvironmentpollution（2）室内小环境污染（2）Indoorenvironmentpollution4电离辐射4Ionizingradiation8

病理和分类

Pathologyandclassification11

解剖学分类

Anatomyclassification1中央型肺癌1Centrallungcancer12

2周围型肺癌2Peripherallungcancer13

组织学分类

Histologyclassification1小细胞肺癌1Smallcelllungcancer,SCLC（1）燕麦细胞型（1）oatcelltype（2）中间细胞型（2）intermediatecelltype（3）混合型（3）mixedtype14

SmallcellcarcinomaRareinnon-smokersLargehilarmass70%presentwithovertmetastasisVerychemo-responsive…Worstprognosis15

Smallcellcarcinoma16

2非小细胞肺癌2Non-smallcelllungcancer,NSCLC（1）鳞状细胞癌（鳞癌）（1）Squamouscellcarcinoma,SCC（2）腺癌和支气管肺泡癌（2）Adenocarcinoma，AC，andbronchoalveolarcarcinoma（3）大细胞癌（3）Largecellcarcinoma（4）鳞腺癌（4）Adeno-squamouscarcinoma17

SquamouscellcarcinomaNow2ndmostcommon(1stinChina)Stronglylinkedwithsmoking60-80%intheproximalairways(centraltype)CavitationTendencytospreadlocally/regionallyPrognosisslightlybetterthanAdenocarcinoma18

SquamousCellCarcinoma19

SquamousCellCarcinoma20

鳞癌21

LungCancerP