脊柱结核专题培训培训课件.pptVIP

SkeletalremainsfromaNeolithicSettlementintheEasternMediterraneanshowprehistorichumans(7000BC)hadTB,andtuberculardecayhasbeenfoundinthespinesofmummiesfrom3000–2400BC

25-4950-99100-3000-910-24300ormoreNoestimateRateper100,000Source:WHO2002.Morbidityrateoftuberculosisin2000

EstimatedTBincidence,prevalenceandmortality,2009

Incidence1Prevalence2Mortality(excl.HIV)WHOregionNo.inthousands%of?globaltotalRate?per100?000pop3No.inthousandsRate?per100?000pop3No.inthousandsRate?per100?000pop3Africa2?80030%?3403?900?450?430?50TheAmericas?2702.9%?29?350?37?202.1EasternMediterranean?6607.1%?1101?000?180?99?18Europe?4204.5%?47?560?63?62?7South-EastAsia3?30035%?1804?900?280?480?27WesternPacific1?90021%?1102?900?160?240?13Globaltotal9?400100%?14014?000?1641?300?191Incidenceisthenumberofnewcasesarisingduringadefinedperiod.

2Prevalenceisthenumberofcases(newandpreviouslyoccurring)thatexistsatagivenpointintime.

3Popindicatespopulation.FromWHO2010data

FromWHO2010data

MycobacteriumTuberculosisacid-fastbacillus

RobertKochfoundTBbacilliin1882Theday,March24,hedeclaredhisfindingsinBerlin,iscelebratedasWorldTuberculosisDayfrom摄于柏林Charite医院

BacillumCalmette-Guérin,orBCG,forshort（1921）LéonCharlesAlbertCalmette（1863-1933）Jean-MarieCamilleGuérin(1872–1961)

Antibioticchemotherapy:thecornerstonestreptomycin（1946）isoniazid（1951）pyrazinamide（1956）rifampicin（1965）ethumbutol（1961）----first-linedrugsSelmanWaksman

SongoftheBurialofFlowers------Iholdaburialwhenyoudietoday,Butthere’snotellingwhenIpassaway.尔今死去侬收葬，未卜侬身何日丧？Otherslaughatmethathaveburiedthee,Whowillbetheonethatshallburyme?侬今葬花人笑痴，他年葬侬知是谁？Theendofspringmakesflowersfallonebyone,It’salsothetimewhenbeautymeetsitsdoom.试看春残花渐落，便是红颜老死时。Oncebeautyiscarriedtoitsverytomb,Bothbeautyand