4-Chlorochalcone-生命科学试剂-MCE.pdfVIP

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4-Chlorochalcone

Cat.No.:HY-W325160

CASNo.:956-04-7

分⼦式:C₁₅H₁₁ClO

分⼦量:242.7

作⽤靶点:MonoamineOxidase;Cholinesterase(ChE)

作⽤通路:NeuronalSignaling

储存⽅式:Storeatroomtemperature3years

*Insolvent:-80°C,6months;-20°C,1month(Storeatroom

temperature3years)

BIOLOGICALACTIVITY

⽣物活性4-Chlorochalcone(Compound3)是⼀种单胺氧化酶(MonoamineOxidase)抑制剂(hMAO-B:IC50=0.082μ

M，hMAO-A:IC50=9.95μM)。4-Chlorochalcone对胆碱酯酶(cholinesterase)也有抑制活性(AChE:IC50=

2.79μM)。4-Chlorochalcone是查尔酮衍⽣物。

REFERENCES

[1].OhJM,etal.Potentandselectiveinhibitionofhumanmonoamineoxidase-Bby4-dimethylaminochalconeandselectedchalcone

derivatives.IntJBiolMacromol.2019Sep15;137:426-432.

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