4-Chloro-1-butyne-4-Chlorobut-1-yne-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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4-Chloro-1-butyne

Cat.No.:HY-W094977

CASNo.:51908-64-6

Synonyms:4-Chlorobut-1-yne

分⼦式:C₄H₅Cl

分⼦量:88.53

作⽤靶点:PROTACLinkers

作⽤通路:PROTAC

储存⽅式:Pureform-20°C3years

4°C2years

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性4-Chloro-1-butyne(4-Chlorobut-1-yne)是⼀种PROTAClinker，可⽤于合成PROTAC分⼦。

体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE382ubiquitinligase

andtheotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto

selectivelydegradetargetproteins.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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