4H-Tomentosin-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

4H-Tomentosin

Cat.No.:HY-N17669

CASNo.:68776-19-2

分⼦式:C₁₅H₂₂O₃

分⼦量:250.33

作⽤靶点:EpoxideHydrolase

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性4H-Tomentosin是⼀种混合竞争型可溶性环氧化物⽔解酶(sEH)抑制剂，IC50为6.84μM，Ki为7.02μM。

4H-Tomentosin通过与Tyr343、Ile363和Tyr383形成氢键与sEH相互作⽤[1]。

REFERENCES

[1].HeX,etal.NaturalsolubleepoxidehydrolaseinhibitorsfromInulaheleniumandtheirinteractionswithsolubleepoxidehydrolase.IntJ

BiolMacromol.2020Apr29:S0141-8130(20)33090-7.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师