旋转恒定磁场治疗激素性股骨头坏死的效果与病理机制.docxVIP

旋转恒定磁场治疗激素性股骨头坏死的效果与病理机制

【摘要】【目的】探讨旋转恒定磁场(RPMF)治疗激素性股骨头坏死的疗效和病理机理。【方法】制备新西兰兔股骨头坏死动物模型，予旋转恒定磁场(铋铁硼永磁体以8Hz频率旋转、形成其上方20cm直径60cm的半球形磁场、表面强度在～T之间)处理4周和8周，使用组织切片和X线片以及显微CT观察股骨头内部结构变化，同时监测其血液黏稠度、胆固醇、甘油三酯以及髋关节腔压力等的变化，和相应阳性假处理4周、8周组(B1组“B2组)、空白对照(C组)进行统计学分析和比较。【结果】经旋转恒定磁场(RPMF)处理后，动物模型的股骨头骨小梁形态结构显着改善，尤以显微CT表现明显，髋关节腔压力、血液流变学及血脂检测值改善具有显着统计学意义(P),与时间因素的交互作用疗效次之。【结论】磁场可以针对股骨头坏死主要环节高脂血症、血液黏稠度增加、关节腔压力增高等发挥调节作用，有效治疗激素性股骨头坏死，尤其是早期病变；显微CT在诊断激素性股骨头坏死方面具有灵敏性和直观的优越性。

【关键词】旋转恒定磁场(RPMF)；激素性股骨头坏死；新西兰兔；显微CT

Abstract:【Objective】Tostudytheeffectandtherapeuticmechanismofrotatingpermanent-magneticfield(RPMF)forthesteroid-inducednecrosisoffemoralhead.【Methods】NewZealandrabbitmodelofsteroid-inducednecrosisoffemoralheadbeingestablished,wereexposedtoRPMFfor4weeksand8weeks(A1/A2group),thenX-ray,micro-CT,andpathologicalexaminationwereadoptedtoobservedthechangeoffemoralhead,bloodviscosity,serumcholesterol,triglycerideandpressureincoxaarticularcavityweremeasuredandanalyzedstatisticallywiththatofcontrolgroup(B1andB2)andshamgroup(C).【Results】AfterRPMFtreatment,theosteogenesisregenerationofnecroticfemoralheadofrabbitmodelhadimproved,especiallyshownmarkedlybymicro-CT,andbloodviscosity,serumcholesterol,triglycerideandpressureincoxaarticularcavityhadsignificantlydescendedcomparedwiththatofcontrolgroupB(P),theeffectofRPMFwasbetterthanthatoftheinteractionoftimefactor(Eta2AEta2A*BEta2B).【Conclusion】RPMFcanregulatedthecourseoffemoralheadnecrosisinvariouscritical-aspects,willbeapromisingmeasureofthepreventionantreatmentofsteroid-inducednecrosisoffemoralhead,especiallyontheearlystage;micro-CTfeaturesdiagnosticsuperiorityofsubstantivityandsensitivity.

Keywords:rotatingpermanent-magneticfield(RPMF);steroid-inducednecrosis;NewZealandrabbit;micro-CT

激素性股骨头坏死是一种严重的医源性致残性疾病，早期诊断及治疗困难，激素应用引起血液黏稠度增加、骨髓细胞