AMG-8562-生命科学试剂-MCE.pdfVIP

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AMG-8562

Cat.No.:HY-114583

CASNo.:1041478-78-7

分⼦式:C₂₄H₂₅F₃N₂O₂

分⼦量:430.47

作⽤靶点:TRPChannel

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AMG-8562是⼀种TRPV1调节剂。AMG-8562可阻断Capsaicin(HY-10448)对TRPV1的激活，但不影响热激

活。AMG-8562可增强pH5对TRPV1的激活。AMG-8562在疼痛模型中可阻断Capsaicin诱导的畏缩⾏为。

AMG-8562在CFA和⽪肤切⼝诱导的热痛觉过敏以及Aceticacid(HY-Y0319)诱导的扭体模型中均显⽰出显著

疗效[1]。

IC50TargetTRPV1

REFERENCES

[1].VayL,etal.Currentperspectivesonthemodulationofthermo-TRPchannels:newadvancesandtherapeuticimplications.ExpertRev

ClinPharmacol.2010Sep;3(5):687-704.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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