AGK2-Standard-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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AGK2(Standard)

Cat.No.:HY-100578R

CASNo.:304896-28-4

分⼦式:C₂₃H₁₃Cl₂N₃O₂

分⼦量:434.27

作⽤靶点:Sirtuin;ReferenceStandards;Apoptosis

作⽤通路:CellCycle/DNADamage;Epigenetics;Others;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AGK2(Standard)是AGK2(HY-100578)的分析标准品。本产品⽤于研究及分析应⽤。AGK2是⼀个选择性

SIRT2抑制剂，其IC50值为3.5μM。AGK2抑制SIRT1和SIRT3，IC50值分别为30和91μM。

IC50TargetIC50:3.5μM(SIRT2),30μM(SIRT1),91μM(SIRT3)[1]

REFERENCES

[1].TatumPR,etal.IdentificationofnovelSIRT2-selectiveinhibitorsusingaclickchemistryapproach.BioorgMedChemLett.2014Apr

15;24(8):1871-4.

[2].KimHW,etal.Sirtuininhibitors,EX527andAGK2,suppresscellmigrationbyinhibitingHSF1proteinstability.OncolRep.2016

Jan;35(1):235-42.

[3].LiY,etal.Poly(ADP-ribose)polymerasemediatesbothcelldeathandATPdecreasesinSIRT2inhibitorAGK2-treatedmicroglialBV2

cells.NeurosciLett.2013Jun7;544:36-40.

[4].ZhaoT,etal.Sel