AM-2099-Standard-生命科学试剂-MCE.pdfVIP

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AM-2099(Standard)

Cat.No.:HY-100727R

CASNo.:1443373-17-8

分⼦式:C₁₉H₁₃F₃N₄O₃S₂

分⼦量:466.46

作⽤靶点:SodiumChannel;ReferenceStandards

作⽤通路:MembraneTransporter/IonChannel;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AM-2099(Standard)是AM-2099(HY-100727)的分析标准品。本产品⽤于研究及分析应⽤。AM-2099是电压

门控钠通道Nav1.7的有效，选择性的抑制剂，对⼈类Nav1.7的IC50值为0.16μM。

IC50TargetIC50:0.16μM(humanNav1.7),0.18μM(mouseNav1.7),3.5μM(ratNav1.7)[1]

REFERENCES

[1].MarxIE,etal.SulfonamidesasSelectiveNaV1.7Inhibitors:OptimizingPotencyandPharmacokineticstoEnableinVivoTarget

Engagement.ACSMedChemLett.2016Sep21;7(12):1062-1067.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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