滤泡性淋巴瘤转化：综述与新见解.pdfVIP

AnnHematol

REVIEWARTICLE

Transformedfollicularlymphoma

Thais1NataliaPinChuenZing1CarlosSergioChiattone2

MassimoFederico3StefanoLuminari3,4

Received:3January2017/Accepted:5October2017

#-VerlagGmbHGermany2017

FollicularLymphoma(FL)isthesecondmostcom-KeywordsLymphoma.Lymphoma,follicular.Lymphoma,

montypeofnon-Hodgkinlymphomaandisconsideredtobenon-Hodgkin.Lymphoma,largeBcell.Diffuse.Diffuse

theprototypeofindolentlymphomas.Histologictransforma-largecelllymphoma.Epigenetic.Prognosis,cellneostic

tionintoanaggressivelymphoma,whichisexpectedtooccurtransformation.Celltransformation,neostic.Genetic

atarateof2to3%eachyear,isassociatedwithrapidprogres-transformation

sion,treatmentresistance,andpoorprognosis.Recentmodi-

ficationstothephysiopathologicmechanismoftransformed

follicularlymphoma(t-FL)havebeenproposed,includingIntroduction

geneticandepigeneticmechanismsaswellasaroleforthe

microenvironment.Althought-FLisconsideredadevastatingFollicularLymphoma(FL)isthesecondmostcommontypeof

complication,asitisassociatedwithtreatment-refractorydis-non-Hodgkinlymphoma(NHL)intheUSAandEurope(10–

easeandadismaloutcome,recentdataintherituximabera20%ofNHL),withapproximately15,000newlydiagnosed

havesuggestedthatnotonlyistheprognosissseverethancasesperyear[1,2].Itisconsideredtheprototypeofindolent

reportedinthepreviousliteraturebuttheriskoftransforma-lymphomas,hasanequaldistributionweenmenandwom-

tionisalsolower.Thus,thisstudyaimedtoreviewthemosten,andhasamedianageof65yearsatpresentation[3–5].

recentresearchont-FLinanattempttoterunderstan