Buloxibutid-Standard-生命科学试剂-MCE.pdfVIP

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Buloxibutid(Standard)

Cat.No.:HY-100113R

CASNo.:477775-14-7

分⼦式:C₂₃H₂₉N₃O₄S₂

分⼦量:475.62

作⽤靶点:AngiotensinReceptor;ReferenceStandards

作⽤通路:GPCR/GProtein;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Buloxibutid(Standard)是Buloxibutid(HY-100113)的分析标准品。本产品⽤于研究及分析应⽤。

Buloxibutid(AT2receptoragonistC21)是⼀种类似活性分⼦的，选择性angiotensinIIAT2receptor(⾎管紧

张素IIAT2受体)激动剂，对AT2受体和AT1受体的Ki值分别为0.4nM和10μM。

IC50TargetKi:0.4nM(AT2)and10µM(AT1)[1]

REFERENCES

[1].WanY,etal.Design,synthesis,andbiologicalevaluationofthefirstselectivenonpeptideAT2receptoragonist.JMedChem.2004Nov

18;47(24):5995-6008.

[2].SchwengelK,NamsolleckP,LuchtK,etal.AngiotensinAT2-receptorstimulationimprovessurvivalandneurologicaloutcomeafter

experimentalstrokeinmice.JMolMed(Berl).2016;94(8):957-966.

[3].FatimaN,PatelS,HussainT.AngiotensinAT2ReceptorisAnti-inflammatoryandReno-ProtectiveinLipopolysaccharideMi