Briciclib-sodium-ON-014185-sodium-生命科学试剂-MCE.pdfVIP

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Briciclibsodium

Cat.No.:HY-16366A

CASNo.:865784-01-6

Synonyms:ON014185sodium

分⼦式:C₁₉H₂₁Na₂O₁₀PS

分⼦量:518.38

作⽤靶点:EukaryoticInitiationFactor(eIF);CDK;c-Myc;MDM-2/p53;

Caspase;Apoptosis

作⽤通路:CellCycle/DNADamage;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Briciclib(ON014185)sodium是⼀种真核翻译起始因⼦4E(eIF4E)抑制剂。Briciclibsodium具有⼴谱抗癌活

性，包括套细胞⽩⾎病、乳腺癌、胃癌及⾷管癌细胞。Briciclibsodium降低了cyclinD1和c-Myc的表达，增

强了P53和CleavedCaspase3促凋亡(apoptosis)蛋⽩的表达。Briciclibsodium可⽤于研究造⾎系统肿瘤和

实体瘤。

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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