原位合成高效抗菌活性凹凸棒石负载氯化银纳米粒子复合材料（英文）.docxVIP

研究报告

PAGE

1-

原位合成高效抗菌活性凹凸棒石负载氯化银纳米粒子复合材料（英文）

一、Introduction

1.Backgroundofantibacterialmaterials

(1)Antibacterialmaterialshavegainedsignificantattentionduetotheincreasingprevalenceofantibiotic-resistantbacteria.TheWorldHealthOrganization(WHO)hasreportedthatantibioticresistanceisoneofthemostpressingglobalpublichealththreats.Withtherapiddevelopmentofmedicaltechnologyandtheincreasinguseofantibiotics,theemergenceofantibiotic-resistantstrainshasbecomeamajorchallengeinhealthcare.Inthiscontext,thedevelopmentofnewandeffectiveantibacterialmaterialsiscrucialtocombatbacterialinfectionsandtomaintaintheefficacyofmedicaltreatments.

(2)Traditionalantibacterialagents,suchasantibioticsandantiseptics,oftenhavelimitationssuchassideeffects,developmentofresistance,andenvironmentalcontamination.Silvernanoparticles(AgNPs)haveemergedasapromisingalternativeduetotheirstrongantibacterialactivityandlowtoxicity.Researchhasshownthatsilvernanoparticlescaninhibitthegrowthofvariouspathogens,includingStaphylococcusaureus,Escherichiacoli,andPseudomonasaeruginosa.Forexample,astudypublishedintheJournalofAntimicrobialChemotherapydemonstratedthatsilvernanoparticleseffectivelykilled99.9%ofE.coliinaconcentration-dependentmanner.Thissuggeststhepotentialofsilvernanoparticlesasapotentantibacterialagent.

(3)Additionally,theuseofnanomaterialsasantibacterialagentshasbeenexploredinvariousapplications,rangingfrommedicaldevicesandwounddressingstocoatingsandtextiles.Onenotableexampleisthedevelopmentofsilvernanoparticle-basedcoatingsformedicalimplantstopreventbacterialcolonization.AccordingtoareportinthejournalBiomaterials,silvernanoparticlecoatingssignificantlyreducedtheincidenceofpostsurgicalinfectionsinpatientsreceivingorthopedicimplants.Furthermore,theinte