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D-520

Cat.No.:HY-120156

CASNo.:1619269-47-4

分⼦式:C₃₁H₃₉N₃O₃

分⼦量:501.66

作⽤靶点:DopamineReceptor;α-synuclein;Amyloid-β

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性D-520是⼀种强效且可透过⾎脑屏障的多巴胺D2/D3受体激动剂(D2EC50=4.73nM,Ki=41.8nM;D3EC50

=2.18nM,Ki=0.35nM)。D-520在体外抑制Aβ聚集体的形成，并促进α-突触核蛋⽩(α-syn)和Aβ聚集

体的解聚。D-520在帕⾦森病(PD)动物模型中显⽰出功效。D-520可⽤于帕⾦森病(PD)和帕⾦森病伴痴呆(

PDD)的相关研究[1][2]。

IC50TargetD2ReceptorD3ReceptorD2LReceptorD3Receptor

4.73nM(EC50)2.18nM(EC50)41.8nM(Ki)0.35nM(Ki)

体外研究D-520(0.01-30μM,24h)exhibitsdose-dependentneuroprotectiveeffectsagainst6-hydroxydopamine(6-

OHDA)(HY-B1081)-inducedtoxicityinMN9Ddopaminergiccells[2].

REFERENCES

[1].YedlapudiD,etal.Targetingalphasynucleinandamy