D2R-D3R-5-HT1AR-agonist-1-生命科学试剂-MCE.pdfVIP

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D2R/D3R/5-HT1ARagonist1

Cat.No.:HY-179713

CASNo.:3028684-07-0

分⼦式:C₂₁H₃₅N₅O₂S

分⼦量:421.6

作⽤靶点:DopamineReceptor;5-HTReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性D2R/D3R/5-HT1ARagonist1(compound22b)是⼀种具有⼝服活性的三靶点D2R/D3R/5-HT1AR激动剂，其

EC50值为1.29,1.05和153.5nM。D2R/D3R/5-HT1ARagonist1可改善MPTP(HY-W114750)诱导的⾏为障

碍，并具有抗抑郁作⽤。D2R/D3R/5-HT1ARagonist1可⽤于帕⾦森病和抑郁症的研究[1]。

IC50TargetD3ReceptorD2Receptor5-HT1AReceptor

1.05nM(EC50)1.29nM(EC50)153.5nM(EC50)

REFERENCES

[1].DuX,etal.Novel2,6-Diamino-4,5,6,7-tetrahydrobenzothiazolederivativesastriple-targetD2R/D3R/5-HT1ARagonistswithrobust

antidepressantandantiparkinsonianactivity.EurJMedChem.2026Feb5;303:118409.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.